Chemotherapy and extreme exercise: A potentially dangerous combination

Teens and prescription drugs: a potentially dangerous combination.

A combination of retinoic acid and proteasome inhibitors for the treatment of leukemias is potentially dangerous.

Retinoic acid (RA) is used in the treatment of leukemias; however, the phenomenon of RA resistance is often the cause of relapse in some patients. In a recent report, Fanelli et al1 showed, using an acute promyelocytic leukemia–derived cell line NB4, that the treatment of RA-resistant cells with proteasome inhibitors restores RA sensitivity. Proteasome inhibitors are already being tested in pha...

A dangerous exercise

Exercise induced anaphylaxis and its subtype the Fooddependent exercise-induced anaphylaxis are uncommon and therefore under-diagnosed forms of physical allergy. Triggers include various degrees of exercise in combination with ingestion of specific food products. Treatment remains identical to that of Immunoglobulin Emediated allergic reactions. The presentation is commonly under diagnosed and ...

A misdiagnosed potentially dangerous shoulder injury.

40 year old engineer presented with a history of chronic left upper limb fatigue and pallor upon limb abduction and intermittent dysphagia. These symptoms caused significant interference with his daily life and had started after a fall onto his left shoulder during a rugby tackle nine years previously. Following the original injury he had attended an accident and emergency department where it w...

Erysipelas: a common potentially dangerous infection.

Erysipelas is an acute superficial cutaneous cellulitis that commonly occurs not only in elderly and immunocompromised persons, but also in neonates and small children subsequent to bacterial inoculation through a break in the skin barrier. Group A Beta-hemolytic streptococcus (GABHS, Streptoccocus pyogenes) is the usual etiologic agent. Factors that predispose pediatric patients to the develop...